HAX’s VC-Founder Industry Hard Tech Matchup is now accepting applications. Register today!

We help startups go further, faster.


Lab & Office


Sq ft Lab & Office Space


HAX & IndieBio Grads


Founders with PhDs


Raised Post-program


SOSV Co-investors
IndieBio SF office

First Check in Deep TechTM

With more than $1.5 billion in assets under management, SOSV makes 200+ deep tech investments per year, including 75 pre-seed and seed rounds in startups that join our industry leading HAX and IndieBio startup development programs. Our pre-seed, “first checks” range from $250,000 to $525,000, and we follow on in later rounds. SOSV is the most active deep tech venture investor in the world.

Smartex founders, HAX

Human & Planetary Health

SOSV’s core mission is to launch visionary founders who are destined to have a radically beneficial impact on human and planetary health. That ranges from the vast effort to make humanity’s means of production more sustainable to curing disease and improving healthcare. As of April 2023, our top 100 climate tech companies have an aggregate valuation of $11.69 billion and have raised $3.77 billion, while our top 100 health startups are valued at $6.47 billion with $1.42 billion raised. SOSV is consistently ranked by PitchBook as a top investor in both categories.

SOSV Founder Sean O’Sullivan

Built for Builders

SOSV’s HAX and IndieBio programs offer 80,000 square feet of bio, chem, mech and EE labs at three locations—New York, Newark and San Francisco. Our founders have access to sophisticated lab and fabrication equipment ranging from 3D printers to mass spectrometers, and they work side-by-side with our GPs and staff to turn their research into scalable commercial reality. 62% of program graduates raise their next round within 12 months.

First of Many Checks
Prototype development at HAX

That Next Check Too

SOSV’s pre-seed or seed investment is just the beginning. With more than 1,000 co-investors in SOSV’s syndicates, we have a powerful global network to match investors with our founders for series seed, A and beyond. We join those later rounds as well, through our core funds as well as the SOSV Select Fund. Between 2020 to 2023, our deep tech portfolio raised $4.02 billion and SOSV joined 449 rounds.

IndieBio SF lab

Diversity for the Win

SOSV believes that great founders come from all geographies, genders and cultures. Our 1,690 deep tech founders represent 75 nationalities and operate in 40 countries. 44% have PhDs earned at 70 universities around the world. And 33% of our startups have at least one female founder. What all SOSV founders have in common is a drive to deliver incredible science and technology that will make the world a better place today and for generations to come.

IndieBio SF demo day

SOSV for Life 

The friendships founders build in the HAX and IndieBio programs last forever, and so do their ties to our general partners, who long remain trusted advisors. We continue helping founders raise funds, make connections, and win press coverage long after they finish our programs. We also produce unique, high profile events to showcase our founders as well as drive the overall climate and health ecosystem, including the SOSV Climate Tech Summit, the SOSV VC-Founder Matchups (Sustainable Industry, Health, and Climate), and our SOSV Climate 100 and Health 100 lists. SOSV is for life.

SOSV Programs

SOSV staff at HAX and IndieBio work with founders around the world

Helping hard tech founders tap into the world’s premier ecosystems for real-world product development, manufacturing and fundraising.
Dedicated to turning scientists into entrepreneurs determined to save lives and save the planet, based in San Francisco and New York City.

Not sure which program is right for your startup?

Learn more about SOSV pre-seed investment and startup development programs.

A Day in the Life of SOSV

Scenes from SOSV’s offices in San Francisco, New York, Newark, and Shenzhen.

Invest with SOSV

SOSV welcomes co-investors in portfolio companies as well as limited partners in SOSV funds

Invest in our Companies

SOSV’s portfolio companies raise 200 follow-on rounds each year, and the co-investors in SOSV’s 1000+ portfolio number in the 100s. SOSV aims to build a global, diverse network of investors, and new co-investors are always welcome.

Invest in our Funds

SOSV is a multi-stage VC that invests in 100+ pre-seed startups each year and joins hundreds of follow-on rounds through SOSV’s core and select funds. New limited partners interested in “human and planetary health” are welcome.

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