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Pear Bio

Ending the spread of cancer


Duleek Ranatunga

CEO & Co-Founder

William Lin

CTO & Co-Founder

Company details

Pear Bio is a computational biology company that has developed a functional precision medicine platform to optimize clinical cancer care and drug development.

The platform uses microphysiological systems and 3D computer vision to measure cancer progression over time. Pear Bio cultures patient tumor samples and immune cells to test potential treatment options and combinations ex vivo. A proprietary computer vision/ML pipeline finds image-based spatial biomarkers in time-course 3D microscopy data of patient microtumor + immune cultures. Each treatment option is compared using these image biomarkers to identify treatments with high potential efficacy for each patient. Patient data and excess tissue feed into a drug discovery pipeline, which allows us to find novel druggable targets in patients who don’t respond to approved therapies.

Pear Bio has tested ~200 patients to date, spanning 9 cancers, and we have internal drug discovery programs against 5 novel druggable targets (4 synthetic lethality and 1 immuno-modulatory).

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