Watch replays of the main stage programming from the SOSV Climate Tech Summit (Nov. 5-6)

Particella

Oral Gene Medicines

Team

Mubhij Ahmad

CEO & Co-Founder

Timothy Day

CSO & Co-Founder

Company details

DNAlite Therapeutics is an early stage pharmaceutical platform developing nucleic acid medicines. mRNA has emerged as a leading therapeutic modality, but delivery remains to be a bottleneck. While current approaches inject mRNA into the bloodstream, DNAlite has created an oral approach to mRNA delivery that survives the stomach and gets taken up by epithelial cells in the gut. Once in the cells, the mRNA is read and the gut cells manufacture proteins – whatever is coded in the mRNA. These epithelial cells naturally turnover and refresh every 3 to 4 days, so DNAlite medicines could be taken on a regular cadence. The proteins expressed can be antibodies and other biologics; it can be equivalent to rare disease gene therapy, but essentially reversible, because no permanent changes are made.

The company has demonstrated proof of platform in-vivo, producing and quantifying proteins from orally given mRNA creating a completely new modality with broad and unique value. They are slated to enter the clinic with IL-22 as their first therapeutic target to tackle indications such as Inflammatory bowel disease (3 Mn
patients in US), Acute graft versus host disease of the gut (incidence of ~5000/yr), and Necrotizing enterocolitis (incidence: ~400/yr in the US).

Get In Touch with Particella

Please tell us a little bit about yourself and why you'd like to get connected. Particella + SOSV will follow up with you via email.

Hidden
Hidden
Hidden
Hidden

No Offer, Solicitation, Advice, or Recommendation

Except to the extent expressly set forth in materials as may be provided through a password protected area on the SOSV website (the "Materials"), or as otherwise expressly specified by SOSV in writing, nothing on the SOSV website or on any platform or other communications medium owned, operated or otherwise by or on behalf of SOSV, is intended to constitute (i) an offer, or solicitation of an offer, to purchase or sell any security, other asset or service, (ii) investment advice or an offer to provide such advice, or (iii) a basis for making any investment decision. Except as expressly stated by SOSV in writing, neither the SOSV website or any platform or other communications medium owned, operated or otherwise by or on behalf of SOSV, nor any of the Materials make any effort to present a comprehensive or balanced description of SOSV or its investment activities. Please note the SOSV Communication Policy available here.