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Heating and cooling make up the majority of energy consumption in buildings, representing over 40% of energy-related greenhouse gas (GHG) emissions. Originating from extensive multidisciplinary research at Rensselaer Polytechnic Institute, MIMiC Systems is pioneering a technology aimed at reducing the emissions from refrigerants in traditional vapor-compression systems, while enhancing thermal comfort without incurring energy penalties. MIMiC employs advanced solid-state heat pumps, known as thermoelectric devices, combined with innovations in power electronics and controls. This approach not only boosts system efficiency but also fully eliminates the need for environmentally harmful refrigerants. The technology is particularly advantageous for retrofitting residential buildings, streamlining the installation process to save both time and labor costs. Moreover, by significantly reducing the number of moving parts, MIMiC’s solution extends the operational lifetime of heating and cooling systems, marking a significant step forward in reducing the environmental impact of building climate control.