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SOSV Key Trends

Deep Tech 100
The Deep Tech 100 is SOSV’s annual list of top 100 portfolio startups on course to bend the arc of deep tech across human and planetary health.
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Climate Tech
SOSV is the world’s leading climate tech investor. The climate portfolio covers all climate categories from energy to transport to ag.
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Human Health
The SOSV health portfolio is the “Shibuya-crossing” of health tech, with companies ranging from assistive robotics to therapeutics, diagnostics, remote care and biomanufacturing.
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Physical AI
SOSV’s Physical AI companies build intelligent machines that sense, decide, and act in the real world, combining AI with robotics, hardware, and advanced manufacturing to solve problems software alone can’t.
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Critical Minerals
Critical minerals are just that—critical, and increasingly in demand with the rise of renewable energy. SOSV invests along the entire critical minerals value chain, from exploration to extraction to processing.
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Women’s Health
In keeping with SOSV’s commitment to deep tech for human and planetary health, SOSV is one the leading VCs in the women’s health field.
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Sustainable Fashion
The fashion industry makes up about 10% of global emissions—so SOSV is investing in a more sustainable fashion future, from plant and waste-based textiles to bio-based pigments and AI that eliminates waste.
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Female Founders
SOSV has invested in 500 women founders, and 1 in 3 of our companies have at least one female founder. Approximately $1 in every $3 that SOSV invests through its core funds goes to a woman-led company.
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Deep Tech 100
The Deep Tech 100 is SOSV’s annual list of top 100 portfolio startups on course to bend the arc of deep tech across human and planetary health.
More
Climate Tech
SOSV is the world’s leading climate tech investor. The climate portfolio covers all climate categories from energy to transport to ag.
More
Human Health
The SOSV health portfolio is the “Shibuya-crossing” of health tech, with companies ranging from assistive robotics to therapeutics, diagnostics, remote care and biomanufacturing.
More
Physical AI
SOSV’s Physical AI companies build intelligent machines that sense, decide, and act in the real world, combining AI with robotics, hardware, and advanced manufacturing to solve problems software alone can’t.
More
Critical Minerals
Critical minerals are just that—critical, and increasingly in demand with the rise of renewable energy. SOSV invests along the entire critical minerals value chain, from exploration to extraction to processing.
More
Women’s Health
In keeping with SOSV’s commitment to deep tech for human and planetary health, SOSV is one the leading VCs in the women’s health field.
More
Sustainable Fashion
The fashion industry makes up about 10% of global emissions—so SOSV is investing in a more sustainable fashion future, from plant and waste-based textiles to bio-based pigments and AI that eliminates waste.
More
Female Founders
SOSV has invested in 500 women founders, and 1 in 3 of our companies have at least one female founder. Approximately $1 in every $3 that SOSV invests through its core funds goes to a woman-led company.
More

Portfolio Companies

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IndieBio NY 09

Asta Bio

Our technology combines 211-Astatine, the most druggable alpha-emitting radioisotope, with multivalent single-domain antibodies to deliver potent alpha radiation that breaks DNA strands and kills the tumor cells while leaving normal cells unaffected.

Locations: United States
Human HealthTherapeuticsPre-SeedTherapeutics
IndieBio NY 09

Bactery

Capturing green energy generated by bacteria found in soil for remote sensors and IoT devices.

Locations: United Kingdom
Climate TechEnergySeedAgTechManufacturing & Energy
IndieBio NY 09

Giraffe Bio

Data-driven biomolecular design to boost the efficiency and sustainability of mining for critical minerals.

Locations: Argentina
Climate TechCritical MineralsEnergySeedSustainable Manufacturing
IndieBio NY 09

heXembio

HexemBio is pioneering the world’s first blood stem cell rejuvenation therapy, a breakthrough platform emerging from >15 Millions from NIH. The company has raised $7.5 million in Seed funding and recently held a successful FDA Pre-IND meeting in January 2026 after being granted Orphan Drug Designation. Its technology, published in Nature, has been featured in […]

Locations: United States
Human HealthTherapeuticsSeedTherapeutics
IndieBio NY 09

Mothership Materials

Capturing new ingredients by molecularly upcycling agricultural waste, paving the way for a sustainable, circular, and traceable bioeconomy.

Locations: United States
Climate TechFemale FoundersMaterialsSeedSustainable Manufacturing
IndieBio NY 09

NanoPlume

Manufacturing the next generation of ultra-insulating, affordable, bio-based aerogels to maximize energy efficiency across multiple industries.

Locations: United Kingdom
Climate TechEnergySeedSustainable Manufacturing
IndieBio NY 09

Quorum Earth

Using the power of the fungal kingdom to develop non-toxic biopesticides to save the bees.

Locations: United States
SeedAgTech
IndieBio NY 09

Semion

Activating plant defense mechanisms silenced during the process of domestication to develop novel pest control solutions.

Locations: Argentina
Pre-SeedAgTech
IndieBio NY 09

Tinkeso Therapeutics

Novel allogeneic Natural Killer T (NKT) cell therapies for oncology and autoimmune diseases.

Locations: United States
Female FoundersHuman HealthTherapeuticsSeedTherapeutics

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