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Princeton Critical Minerals
Originating from Princeton University, Princeton Critical Materials has developed a pioneering approach to lithium extraction, addressing the critical demand surge anticipated as the world shifts towards electrification and electric vehicles. With lithium demand projected to double between 2025 and 2030, Princeton’s Critical Materials technologies emerge as essential solutions. Their initial product line enhances productivity in […]
Duncan Turner Talks About How Trump’s Project Vault Impacts Critical Mineral Startups
Yesterday, Trump announced a $12B critical minerals stockpile program (“Project Vault”) to procure and store critical minerals in the U.S. SOSV General Partner Duncan Turner told Bloomberg that the move signals a meaningful push to build a domestic critical-minerals supply chain – opening the door for next-gen mining, processing, and refining technologies in a sector […]
How HAX Helps Hard Tech Founders Rapidly Prototype, De-Risk Technology & Achieve Traction
Hard tech doesn’t move at the speed of software. To change the physical world, hard tech founders need labs, highly specialized machinery, engineering and design support, supply chain expertise and, of course, capital.
Portfolio
Electrifying Everything: Princeton ZERO Lab’s Jesse Jenkins on our progress a year into the IRA
When Princeton’s Jesse Jenkins releases a new report on net-zero pathways and policy, the climate tech world pays careful attention.
Announcing HAX Plasma Forge's New Home at Princeton’s SRI
Building the next generation of plasma-powered companies in Princeton, NJ.
HAX, One of NJEDA’s Strategic Innovation Centers, Ignites Tech-Based Economic Development
Back in 2018, Governor Phil Murphy set out to strengthen New Jersey as a home for breakthrough innovation by building new Strategic Innovation Centers (SIC), led by the New Jersey Economic Development Authority (NJEDA). Three years later, the NJEDA spotted an opportunity: an RFP from SOSV to select the global headquarters for its hard-tech program, HAX. […]
How X, Breakthrough Energy and Princeton’s ZERO Lab see the impact of the Biden’s Inflation Reduction Act
Unresolved and unstable policies can make it difficult (or expensive) for startups to secure financing. Thus, emerging climate technologies depend to some extent on support from policymakers. But to what extent can climate tech startups and investors shape policy? And how?
Giraffe Bio
Data-driven biomolecular design to boost the efficiency and sustainability of mining for critical minerals.
What Now? From the IRA to "Drill, Baby, Drill" – SOSV Deep Tech LIVE Premieres with Princeton's Dr. Jesse Jenkins
We’re kicking off something big—SOSV Deep Tech LIVE, our brand-new video podcast series, where we explore the frontiers of Deep Tech with the world’s leading technologists, founders, and researchers.
Meet Avra van der Zee, SOSV’s New General Partner
When SOSV and the New Jersey Economic Development Authority (NJEDA) announced a $50 million co-investment to build a new global headquarters for SOSV’s HAX in the heart of Newark in 2022, we knew the stakes were high. But HAX has just the right team to help early stage founders scale their product development and get to market, […]
Augment Biologics
Life is programmed by three classes of biopolymers: polynucleotides (DNA/RNA), polypeptides (proteins), and polysaccharides (glycans). We’ve learned to “write” genes and proteins like software, but glycosylation is still a finicky, expensive manufacturing problem. That’s a big deal: the wrong glycan can slash an antibody’s efficacy, trigger allergic reactions, or turn a multi-million-dollar batch into scrap. […]
HAX 2025 Demo Day
Welcome to the investor portal for HAX 2025 Demo Day. Investors are invited to watch the videos, review the companies’ profiles and decks as well as request meetings. Questions? Contact us at events@sosv.com
Supply Chain Sovereignty: Why Biomanufacturing is Mission Critical
At Closed Loop Ventures and SOSV IndieBio, we are committed to investing in and supporting companies that are revolutionizing manufacturing across industries––enhancing more localized and distributed processing, with less reliance on feedstocks from complex global supply chains.
This September during New York Climate Week, Closed Loop Partners’ Ventures team and SOSV’s IndieBio invite you to an intimate roundtable (Chatham House Rules) on the increasingly urgent need to scale biomanufacturing amidst rapidly changing supply chains.
Date: Wednesday, September 24 | Time: 10:00 AM – 12:00 PM ET | Location: New York City
Cocoon Raises $15M Series A for Critical Cement Substitute
Concrete is the most widely used material on earth after water, and we’re running out of a key ingredient. Widely used cement substitutes, known as supplementary cementitious materials (SCMs), have historically come from heavily polluting coal plants and iron blast furnaces. As those industrial processes are retired across the U.S. and Europe, SCM supply is […]
SOSV Deep Tech 100
We are pleased to inaugurate SOSV’s first annual Deep Tech 100, a list of our startups on course to play a huge role in the future of human and planetary health.
IndieBio SF Demo Day January 30, 2026
You are invited to review the virtual assets, including company profiles, for the startups participating in the demo day.
Protera Biosciences
Protera Biosciences is advancing the science of protein engineering to address critical challenges in food, agriculture, the environment, and human health.
Still Bright
To reach Net-Zero by 2050, the world needs to produce as much copper in the next 26 years as it has produced in all of human history. Clean energy technologies, such as wind energy, solar energy, and electric vehicles require two to five times as much copper as their traditional counterparts. Copper, however, is expected […]
Cool Amps
The US is facing a frightening shortfall in the critical minerals needed for energy storage & batteries to enable the shift to electrification. There are limitations in our ability to mine these locally; however we can find these critical minerals in post-manufacturing, off spec batteries, as well as in growing reserves of post-use, spent batteries […]
TrelliSense
Methane, with a warming potential 85 times greater than CO2, presents a critical challenge in global warming mitigation efforts. Currently, many facilities handling methane lack comprehensive monitoring systems for detecting unintended emissions within their operations. This oversight is becoming increasingly untenable due to evolving regulations, enhanced third-party and public scrutiny, and escalating reporting demands across […]
Mesa Quantum
GPS stands as one of the most remarkable innovations of our era, transcending its use case as navigation tool to become the global reference for time. Utilizing GPS for position, navigation, and timing synchronization in crucial systems such as data centers, the energy grid, and consumer electronics has become indispensable to our economy However, as […]
Navion Energy
Navion Energy specializes in advanced sodium-ion battery technology that offers efficient, cost-effective, and eco-friendly energy solutions. Our cutting-edge batteries, designed with next-generation materials, deliver superior performance and reliability for energy storage applications ranging from auxiliary and backup, to BESS
FloUV
IndieBio has not seen a foodtech company take off this fast since we funded NotCo in 2017. FloUV makes UV-C sterilization systems that are 4x cheaper and draw 10x less electricity than existing systems. These are used throughout the liquids and beverages sector – both in supply chains and in processing/packaging – across dairy, juices, […]
SuperCool Earth
With water scarcity accelerating across the globe, massively reshaping agricultural and energy landscapes, reliable precipitation has become a critical infrastructure play with venture-backed companies, government programs, and utilities alike rushing to fund solutions. Surprisingly, the problem is not related to the lack of water in clouds. In fact, there is actually just as much water […]
Deep Root BioLabs
Industrial pollution and mineral shortages have created an urgent need for sustainable cleanup and resource recovery. Conventional methods rely on excavation and landfill disposal—slow, costly, and damaging to ecosystems. Deep Root BioLabs reprograms plants from the inside out. Using engineered endophytes, microbes that live in plant roots, the company delivers biomolecules that transform plants into […]
🎥 100-Year Quest for Fusion Energy with Steven Cowley, Director, PPPL
Fusion energy has long been called the “holy grail” of clean power because in theory it’s cheap, abundant, clean, and safe. Yet despite 100+ years of scientific research and billions in investment, the profound engineering challenges associated with fusion-based power are far from settled.
Join us for a fireside chat with Sir Steven Cowley, Director of the U.S. Department of Energy’s Princeton Plasma Physics Laboratory (PPPL).
Cowley is widely considered one of the most influential fusion scientists, having spent decades at the forefront of plasma physics, which is the technological key to containing fusion reactions for power generation. In his role at PPPL and prior to that as CEO of the UK Atomic Energy Authority, Dr. Cowley has shaped not only the science of plasma, but also the engineering strategies and global policy discussions around fusion power. For his contributions to science, he was appointed a Knight Commander of the Order of the British Empire (KBE).
Announcing the Main Stage Sessions at the 5th Annual SOSV Climate Tech Summit
We’re excited to announce the 19 main stage sessions for the 5th annual SOSV Climate Tech Summit, taking place November 3–7, 2025. We’ll explore how deep tech founders are turning scientific breakthroughs into scalable climate solutions, and how investors are navigating today’s political and funding headwinds to keep the transition moving forward. Sessions will also […]
HAX's Deep Tech Showcase During NYC Deep Tech Week
Investors! Join HAX in New York on April 1 for Investor Showcase during New York Deep Tech Week featuring 20+ startups ranging from plasma physics to advanced chemistry to critical minerals, and more.
Is New Math the Answer to AI Slop Code?
Logos Research has recently started working with a small and very exclusive set of top universities and quant funds. They are a new entrant among mathematical reasoning companies, joining startups such as Axiom, Harmonic, Math.Inc and Logical Intelligence. Logos stands out for being built by a mixture of world-class mathematicians and quant finance managers, a […]
SOSV Deep Tech Live - The 100-Year Quest for Fusion Energy with Sir Steven Cowley, Director, PPPL
Join us for a fireside chat on April 21, 2026 with Sir Steven Cowley, Director of the U.S. Department of Energy’s Princeton Plasma Physics Laboratory (PPPL).
Sir Steven Charles Cowley is a British theoretical physicist widely regarded as one of the world’s leading authorities on nuclear fusion. Since 2018 he has been the Director of the Princeton Plasma Physics Laboratory, one of the U.S.’s flagship fusion energy research centers, after having been CEO of the UK Atomic Energy Authority from 2009–2016 and head of the Culham Centre for Fusion Energy, where he led the United Kingdom’s national fusion research program.
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The First Check in Deep Tech®
SOSV is the world’s most active deep tech venture capital firm investing at pre-seed, with deeply resourced locations for founders in New York, Newark, and San Francisco.
Meet 20+ HAX Deep Tech Startups at New York Deep Tech Week
Investors! Join HAX in New York on April 1 for an Investor Showcase during New York Deep Tech Week featuring 20+ startups ranging from plasma physics to advanced chemistry to critical minerals, and more.
IndieBio is Now SOSV NY & SOSV SF, Underscoring SOSV’s Leadership in Deep Tech
In 2015, SOSV opened IndieBio San Francisco, Silicon Valley’s first biotech program that offered bio-labs as well as pre-seed investment to scientists ready to launch startups. IndieBio took the world by storm and biotech investing surged. In 2020, SOSV opened a second IndieBio in New York City. Between 2015 and 2025, IndieBio’s 310 graduates raised […]
🎥 Plasma Beyond Fusion: Powering Next Gen Semiconductor Manufacturing & Materials
At our latest SOSV Deep Tech Live, we sat down with a panel of world leaders in plasma to explore how plasma is quickly becoming one of the most important…and misunderstood..forces shaping the future of semiconductors, clean manufacturing, advanced materials, and of course, clean energy. While much of today’s AI conversation centers on LLMs that […]
Here are videos for all the sessions at the 2022 SOSV Climate Tech Summit
We just completed our two-day summit (Oct. 25-26), which included 22 panels and fireside chats with leading founders, VCs, researchers and policy experts. We had a great turnout, with more 6700 people registered this year, from 88 countries. We recognize that the event was not available during waking hours in much of the world so we wanted […]
A year in, HAX in Newark is in full swing with ten companies and its first funding announcement
Today, HAX is up and running in Newark, with a 10-year lease for 35,000-square-feet at 707 Broad Street in historic downtown Newark, 10 new hires, 10 new startups in residence, and a growing number of local partnerships.
On Demand: All the SOSV Climate Tech Summit 2023 main stage sessions
We just wrapped the SOSV Climate Tech Summit! We recognize that not everyone could stay in place for 12 hours of panels and firesides over two days, so we worked over time to make each of the main stage sessions available on YouTube. Coordinates below! Here’s the complete playlist for Day One (Sept. 26) and […]
A Recap: SOSV at NY Climate Week 2025
And that’s a wrap! Climate Week NYC 2025 was once again packed with energy and ideas, and for us, much of the action centered around The Biome, SOSV’s event space in Midtown Manhattan. SOSV and our partners (including Honda Xcelerator Ventures, Greentown Labs, Canary Media, Kompas, and more) hosted 11 events that attracted over 1,000+ […]
Q&A: Augment Bio, Glycosylation by Design
Our entire biotech sector is built on the ability to control two of life’s foundational biopolymers – think DNA and proteins. Recombinant biotechnology, gene editing – being able to program life has unlocked incredible value. But controlling the third class of biopolymer has been tricky. Long chains of sugars called glycans cluster on every surface […]
Fermeate
Canyon Magnet
As we look toward to 2050, global energy needs will be doubled. Fusion energy is the most promising solution and has attracted $6 billion investment over the last 5 years. The total cost of fusion reactor is around $1B, and currently magnet cost makes up half of this cost. High temperature superconductor (HTS) magnets are […]
Soliome
Sóliome is using peptides to make the world’s safest suncreen, both for humans and for the environment. Based on groundbreaking work in protein engineering at Princeton University, Sóliome has reinvented sunscreens, an $18 billion global market. We are developing effective protein-based sunscreens. that are safe for all of life, provide broad-spectrum protection, and that feel […]
Announcing HAX's Sept. 11 San Francisco Demo Day
Join SOSV’s HAX Demo Day to hear pitches from 25 startups categories including industrial and maritime decarbonization, critical minerals, automation, diagnostics and more.
IndieBio New York 2025 Demo Day
Welcome to the investor portal for IndieBio’s February 12 Demo Day. Investors are invited to review the companies’ profiles and decks as well as request meetings. Questions? Contact us at events@sosv.com Welcome to the public portal for IndieBio February 12 Demo Day. You are invited to review the virtual assets, including company profiles, for the […]
SOSV & Women Moving Markets presents: Commercializing Deep Tech for Industrial Resilience
The commercialization of deep tech—critical innovations in energy, manufacturing, and materials—has never been more urgent. As global supply chains shift and industrial strategy takes center stage in policy discussions, how do startups, investors, and corporates navigate this evolving landscape?
Join us for a compelling discussion with:
– Dr. Vanessa Chan, Inaugural Vice-Dean Innovation & Entrepreneurship at Penn Engineering and Former Chief Commercialization Officer, U.S. Department of Energy
– Dr. Susan Schofer, Partner & Chief Science Officer, HAX (SOSV)
IndieBio New York 2026 Investor Showcase
Welcome to the public portal for IndieBio New York’s March 11 Investor Showcase
SOSV Deep Tech Live: Rick Gottscho on Plasma's Role in Semiconductor Fabrication & Physical AI Infrastructure
Plasma is the foundational technology behind semiconductor fabrication — and without it, Moore’s Law would have stalled decades ago. Now, as silicon transistors hit their physical limits, the industry is turning to new materials, chip architectures, advanced packaging, and novel device physics to sustain performance gains, improve energy efficiency, and reduce compute costs, all while navigating the explosive demand driven by AI.
At this critical inflection point, we’re joined by Dr. Rick Gottscho, Retired Head of Products & CTO of Lam Research, who will make the case for why plasma’s most important moment is right now.
Innatrix
Innatrix’s seasoned team of AgriTech professionals are working to replace agrochemical with biological pesticides for farmers. They have developed a robust pipeline for identifying novel biopesticides to control three economically important and critical pathogens, such as late blight, soybean cyst nematode and citrus greening.
Q5D
Wiring is the critical element that makes so many of moder-day products function. Despite major advances in our approach to these products and their manufacturing, wiring of these products is still made by hand. This renders the wiring process expensive and labour intensive, error prone, leaving us with long and fragile supply chains. Q5D is […]
Lura Health
Americans and humans globally are facing multiple health crises, as they are plagued by chronic disease, which require consistent tracking in order to provide effective treatment. Generation of continuous data for monitoring and controlling these diseases is essential, as single-point tests do not effectively measure long-term trends, cannot provide early, proactive alerts, and do not […]
Grounded AI
Grounded AI (previously RockMass) provides geologists with mobile data collection tools to collect structural data more efficiently, accurately, and safely.
OaCP IE LTD
Cancer diagnosis is a race against time. Traditional DNA tests are slow, costly, and often lead to delayed treatments. OACP’s innovative technology dramatically accelerates this critical process, providing doctors with faster, more accurate results. By slashing diagnosis time by 97%, we’re helping to improve patient outcomes and reduce the overall burden on healthcare systems. OaCP-patented […]
Protonintel
Protonintel provides continuous, real-time, and accurate biomarker monitoring to better manage chronic disease and save lives. The ProtonPetal will be the only solution to provide accurate and real-time potassium (K+) measurements in the interstitial fluid of the skin continuously for heart and kidney care. Data from the ProtonPetal can be monitored by clinicians and end […]
CanCan
CanCan is a cloud-based software service that provide real-time, critical financial and management information to SME owners and managers. With our team of financial and accounting consultants, software professionals, and business management experts, CanCan also improves the productivity of employees and accountants by digitalizing business flows and connecting them to financial systems.
Coffee Exchange
Coffee Exchange develops technologies to streamline & increase transparency in critical supply chains in the Global Coffee Industry. Our B2B e-commerce platform connects over 1000 coffee roasters in China and now over 200 in the USA directly to coffee exporters. CEx provides logistics, customs clearance, warehousing, marketing and sales for green coffee exporters in Ethiopia, […]
Diadem Biotherapeutics
Diadem Biotherapeutics, Inc. is a platform therapeutics company developing a broad pipeline of first-in-class immunotherapies. Diadem is engineering exosomes to be inhalable cell-specific immune modulators. Exosomes are small, virus-sized particles released by cells to communicate throughout the body. Leveraging expertise in genetic engineering and scalable bioprocessing, Diadem is developing cell secreted nanovesicles precisely engineered to […]
Kutanios
Kutanios produces a peptide-based ingredient that prevents skin damage from aging and sun exposure via topical application. The novel mechanism stops skin cells from degrading the surrounding collagen and promoting inflammation, common causes of sun damage-related aging. Not only does this peptide protect against sun and skin damage but the ingredient is also biodegradable and […]
Markit
Markit allows brands to rapidly experiment and collect critical early user feedback on new products and services. We create low-cost viral marketing campaigns encouraging customers to earn free trials and samples if they promote products to their networks. In only 3 months, Mark It has reached over 200K WeChat mini program users.
Bioeutectics
Bioeutectics has developed a technology capable of revolutionizing today’s industrial processes by supplying the next generation of green solvents. The company’s non-toxic, biodegradable, and sustainable solvents use a combination of readily available plant by-products and eutectic technology. AI-enhanced green chemistry allows the customization of products for use in a variety of industries such as food, […]
Mazlite
Spraying and coating is a 220+ billion dollar market. From cars to crops, from boats to batteries – spraying is a critical operation in many multi-billion dollar industries globally. But today’s practices are far from perfect. Specifically current spray processes for automotive are highly inefficient. These processes are high in cost, making up 30% of […]
TippingPoint Biosciences
Packaging of our DNA into chromatin is critical for dictating which parts of the genome can be transcribed and which cannot. TippingPoint Biosciences is the first company to tackle the core problem of targeting and drugging only the defectively packaged regions of the cancer genome, without affecting other correctly packaged regions. The TippingPoint platform leverages […]
VIA Fuels
Founded by veterans of oil & gas, coming together with synbio experts, VIA Fuels makes decarbonized jet fuel. Their “shortcut” is jumping straight to an 8-carbon cycloalkane, rather than using multiple, expensive catalytic steps. Cycloalkanes are critical to jet fuel. VIA Fuels uses extra-long-run fermentation where – because of the unique characteristics of their target […]
LightHearted AI
One in two people over age 65 have an undiagnosed heart valve disease. This leads to hundreds of thousands of individuals per year being diagnosed in critical condition during a hospital admission or, worse, at autopsy due to poor diagnostic accuracy in primary care, as well as billions of dollars being spent yearly to treat […]
Terra Bioindustries
Discarded food accounts for 8-10% of greenhouse gas emissions and costs the global economy $940 billion per year. Upcycling surplus food is therefore critical to decarbonizing the food supply chain and curbing its massive appetite for water and deforested land. Terra Bioindustries has developed a negative-emissions platform for upcycling brewer’s spent grain, a beer byproduct […]
BryoSphere Biotechnologies
BryoSphere Biotechnologies uses moss plants and biotechnology techniques to synthesize rare, plant-derived specialty compounds. By harnessing the genetic information of a variety of plants, BryoSphere achieves the production of rare compounds with significantly higher yields compared to those found in their natural counterparts, thereby enhancing accessibility. Currently, BryoSphere is dedicated to the development of two […]
Terran Robotics
The United States is grappling with a significant housing shortage, with the rate of new home construction still trailing behind the pre-2008 financial crisis levels. The scarcity of new housing, coupled with high costs stemming from a limited labor pool and fluctuating raw material prices, exacerbates this issue. Terran Robotics offers an innovative solution by […]
Qnetic
Meeting decarbonization targets necessitates the development of substantial grid-scale storage solutions that can charge and discharge twice a day. The use of lithium-ion (Li-ion) technology, while prevalent, becomes economically challenging for multiple daily cycles, due to accelerated degradation and decreasing performance over its usable lifetime. This leads to high cell replacement costs and also limits […]
AtoMe
To support a world desperately seeking clean energy, materials innovation needs to match the pace of design innovation. Applications such as nuclear power, aerospace, wind energy, traditional energy & thermal power, can all benefit from materials with enhanced operational performance. Specifically new structural materials are needed with higher temperature tolerance, enhanced strength and toughness, robust […]
Mothership Materials
Capturing new ingredients by molecularly upcycling agricultural waste, paving the way for a sustainable, circular, and traceable bioeconomy.
Hidrogenics
Hidrogenics solves the problem of current methane pyrolysis technology which is the production of low value carbon product (mostly carbon black). Hidrogenics directly convert methane into value added carbon with value up to 200000 higher than carbon black as well as turquoise hydrogen. Note than both product categories are in high demand in the US […]
Danu Robotics
Danu Robotics offers an AI-guided multi-picker robotic sorting system to fully automate waste sorting processes, increasing efficiency and revenue for recycling facilities.
XEra Energy
XEra Energy Inc. (San Francisco, 2024) reclaims critical minerals, like Ni and Li, from batteries or ore concentrates using innovative hydro-separation and purification process, creating a closed-loop cathode materials to support battery manufacturing for decades to come.
Nascent Materials
The U.S. lithium-ion battery industry is at a critical inflection point. More than 90% of cathode materials are produced in Asia—creating a massive cost and security gap in U.S. battery production. Nascent’s mission is to close that gap. We develop and scale advanced manufacturing technologies that: •Reduce dependence on imports •Lower production costs •Accelerate the […]
Cortisys
Cortisys is building an automated, standalone neuromodulation platform to deliver mental healthcare at scale. Their system uses multi‑locus Transcranial Magnetic Stimulation (mTMS) to stimulate multiple critical brain networks non‑invasively, drug‑free, and with high patient tolerability. By automating complex setup and positioning steps that currently require specialized personnel, Cortisys unlocks neuromodulation for many more clinics and […]
Introducing the HAX Plasma Forge: A New Era for Plasma in NJ
At SOSV, we believe deep tech has the power to unlock world-changing solutions, and that means investing not just in startups, but in the infrastructure, expertise, and ecosystems that support them. That’s why we’re thrilled to announce the HAX Plasma Forge! This new facility will be based in the Princeton, NJ area and will be […]
SOSV bets plasma will change everything from semiconductors to spacecraft
Plasma, the fourth state of matter, is one of the most exciting frontiers in science. Best known for its role in powering fusion energy, plasma’s potential extends far beyond. From catalysis that enables ultra-efficient chemical transformations, to rocket propulsion, to next-gen AI chips, plasma opens entirely new pathways for innovation previously impossible. That’s why HAX, […]
Cephia Secures $4M Seed Funding to Revolutionize Multimodal Sensing with Metasurface Technology
Excited to announce that Cephia, an SOSV portfolio company building products using advanced AI computational imaging technologies and silicon sensors made from advanced metamaterials, launched with several pilot customers and $4 million in seed venture capital funding. Cephia sits at the intersection of machine vision, robotics, and edge AI, addressing a rapidly expanding “physical AGI” […]
Ten Takeaways from the 2023 SOSV Climate Tech Summit
If you missed some of the 12 hours of interviews and panels (video | podcast replays), or the 10 hours of live AMAs with investors (video replays), here is a quick take on the highlights of our third annual SOSV Climate Tech Summit. But first, we’d like to offer our heartfelt gratitude to the 100 […]
Deal With the Feels: 8 Words That Can Shift You to Success
One question, one answer. An eight word shift to success through calm. “What am I feeling?” “I accept I feel…” These eight words have recently changed my life.
The HBDI assessment once saved SOSV. It can help your founding team, too.
Every Picard needs a Geordi La Forge
What the FOAK? Funding First-of-a-Kind Climate Tech Projects With Prime Coalition, Generate Capital, and the DoE’s Office of Clean Energy Demonstrations
Climate tech, whether it’s renewable energy or cell-cultured protein, only makes a difference at scale, and scale is fast becoming the biggest challenge of all.
Climate Summit: How Gaia, Kayrros, and Pano Monitor Forests, Emissions, and Wildfires
For the most part, public institutions collect the data used to understand and model climate change. Recently, though, climate tech startups have begun to fill in the data gaps.
Material Innovation Report 2025: The Green Rush
In the Sourcing Journal’s 2025 Material Innovation Report, Sabriya Stukes, partner at SOSV and chief scientific officer at IndieBio, weighs in on the growing urgency and opportunity around sustainable materials. She discusses the environmental toll of fashion, the return of VC interest in biomaterials, and why SOSV backs both new materials and the tools that […]
Join SOSV at Climate Week NYC 2025
Climate Week NYC is one of the world’s leading global climate gatherings and it’s just around the corner! But this one feels a bit different. In past years, we came together with a sense of optimism. This year, we come with urgency. Washington’s retreat from climate programs and the venture market’s pullback from climate tech […]
2026 Climate Hard Tech Predictions From Po Bronson: Circularity & Manufacturing Bets that Matter
What does SOSV General Partner Po Bronson see when he looks into Climate Hard Tech’s 2026 Crystal Ball? He recently broke down some thoughts for Climate Hack:
Avalo.ai: An Agricultural Revolution Through AI Plant Evolution
Picture this: Acres of cotton all around you. 150,000 plants. Now, harvest them all, collect the seeds — all 45 million of them — and start sequencing genomes.
ProtonIntel: The First Ever Continuous K+ Monitoring
Proton Intelligence is developing the first ever continuous wearable kidney health monitoring platform, starting with potassium.
About SOSV
SOSV’s mission to support “human and planetary health” spans the globe with 1000+ startups operating in 60 countries and SOSV programs based from New York City and Newark, to San Francisco, Shenzhen, Shanghai and Tokyo. Everywhere, we’re helping founders go further, faster.
Sean O'Sullivan
After Sean O’Sullivan’s first startup went public in 1994, he founded SOSV in 1995 as a “super angel.” In 2007, based off the success of two dozen investments that had done remarkably well, Sean began expanding SOSV and transitioning it from a personal investment vehicle into an organization which today has over 80 staff supporting […]
Pae Wu
Pae Wu is a General Partner at SOSV and Chief Technology Officer at SOSV SF. Her portfolio includes companies destroying forever chemicals in our water, deploying advanced sensors to keep the public safe, and dramatically reducing our dependence on petroleum. Pushing technology’s limits to address intractable problems is the common thread in Dr. Wu’s work […]
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IndieBio Demo Day 16
Welcome to the investor portal for IndieBio San Francisco Demo Day 16. Investors are invited to watch the videos (click the images), review the companies’ profiles and decks as well as request meetings. Questions? Contact the IndieBio team individually through LinkedIn or this contact form.
The SOSV Climate Tech Summit
The main stage agenda will feature top founders, VC investors and policymakers who are at the heart of the climate tech ecosystem, and their conversations will focus on how to make the startup ecosystem go further, faster — for the same of the planet and humankind. Read more. In addition, leading early stage VCs and […]
Team
We’ve founded global organisations, grown startups, planted 10 million trees, completed IPOs, rebuilt Iraq, and invented technology that has changed our world for the better.
Sabriya Stukes
Sabriya is a Partner at SOSV and Chief Scientific Officer for SOSV NY. Prior to joining, she was Operations Director for Stellate Therapeutics, a biotech company developing microbiome-derived therapeutics to treat neurodegenerative diseases. After earning her PhD in Biomedical Sciences from the Albert Einstein College of Medicine, she was the founding Associate Director for the […]
Press
The SOSV comms team is alway ready to help journalists seeking expert perspective connect with our general partners and the founders in our portfolio.
SOSV's Growth Summit - Summer '22
In this summit we will cover: – *Product Management* – TikTok USA product manager will compare the “East (TikTok) vs. West (FB, IG) product mindset” – *Branding* – Brand expert to Starbucks and Startups presents “3 Critical Factors that Make or Break Your Startup Brand” – *Content Marketing & SEO* – Grow to 1M+ Traffic […]
New Human Health Frontiers
Speakers include: – Harvey Tian, CEO of Inso Bio – Mehdi Javanmard, CEO of RizLab Health – David Bravo, CEO of Pannex Therapeutics The event will include startup pitches, a moderated discussion among panelists, and the opportunity to network with other attendees.
HAX Demo Day May 1 in Newark
Investors! Join HAX for a Demo Day on May 1 featuring 20+ hard tech startups. In-person at HAX’s new office in Newark or online.
Legal FAQs
At SOSV we believe in the power of educating our startups right from the get-go to equip them with the knowledge they need to grow their companies.
What are SOSV’s Vesting Requirements?
What is Vesting? Vesting is the process of earning your shares over time. Once your shares have vested you can exercise them. Vesting helps to encourage Founders and employees to commit to the Company for longer than they might otherwise. A typical vesting schedule is over four years with a one year cliff. This means […]
HAX 2024 San Francisco Demo Day
Welcome to the investor portal for HAX San Francisco Demo Day. Investors are invited to review the companies’ profiles, pitch decks as well as request meetings. Questions? Contact us at events@sosv.com
SOSV’s VC-Founder Matchup Event # 1 Women’s Health – February 3–7
Join SOSV’s first virtual matchmaking event focused on Women’s Health, happening February 3–7, 2025. The event is open to founders and investors. It is 100% virtual and free.
SOSV Matchups
SOSV Matchups are VIRTUAL, GLOBAL and FREE matchmaking events focused on specific themes and open to investors and early stage founders worldwide.
SOSV/HAX : Electrochemistry and the Future of Manufacturing
Join us at Newlab in Brooklyn as SOSV’s HAX discusses the role of electrochemistry as a key technology to decarbonize our economy. We are bringing together a diverse group of experts and entrepreneurs for a vibrant discussion.
Panelists:
- Dr. Susan Schofer – Partner & Chief Science Officer, HAX
- Dr. Miguel Modestino – Director of Sustainable Engineering Initiative and Professor of Chemical Engineering, NYU
– Dr. Christopher Reyes, Ph.D – CTO & Co-Founder, Material Hybrid Manufacturing, Inc.
– Will Purvis, CEO & Co-Founder, Kaio Labs
Avra van der Zee
Avra is a General Partner at SOSV HAX where she leads global climate investing strategy. Avra is a seasoned climate entrepreneur and investor specializing in scaling startups. With a background rooted in operations, Avra joined SOSV after five years as COO of Elemental Impact, where she oversaw investments, communications, and operations, and helped steer the […]
SOSV HAX 2026 Investor Showcase
Welcome to the investor portal for HAX 2026 Deep Tech Showcase. Investors are invited to review the companies’ profiles and decks as well as request meetings. Questions? Contact us at events@sosv.com
SOSV Deep Tech Summit
We decided to broaden the Climate Tech Summit because so many remarkable, frontier technologies, AI not the least, are leveling technical challenges once thought insurmountable across every deep tech category. Focusing on climate alone left too much out of the conversation, especially given SOSV’s broader mandate to address human and planetary health. That said, SOSV remains as committed as ever to climate tech, and the momentum lost under the present US administration only makes the mission more critical.
Announcing the First Round of Speakers for the SOSV Climate Tech Summit
There’s no looking away from what 2025 marks for climate tech investing. The Trump administration’s One Big Beautiful Bill Act (OBBBA) has rolled back much of the Inflation Reduction Act (IRA) and undercut investors’ confidence in many climate tech categories. At the same time, there is no shortage of founders making incredible progress. What they […]
The word on the 2022 SOSV Climate Tech Summit and Matchup
The second annual SOSV Climate Tech Summit took place in a world far different from the first. Conflict in Ukraine, surging inflation, supply chain disruptions, and the rise in extreme weather events dimmed last year’s exuberance. At the same time, across the summit’s 20 hours of programming on Oct. 25 and 26 there was no […]
Meet Pae Wu, the new general partner at SOSV’s IndieBio in San Francisco
Pae Wu is the newest general partner at SOSV. She runs IndieBio SF with fellow SOSV general partner Po Bronson. Pae is also the CTO of the program.
SOSV 2021: The Year in Review
To take a company from the founding team with an idea to a product and a global success story takes years, if not a decade or more. That’s especially true for very early stage investors, who write the first check to a founder with no revenue and no working prototype.
SOSV announces the close of its $100M Select Fund, the venture investor’s first growth stage fund
SOSV announced today the close of the SOSV Select Fund, which reached a$100 million hard cap and marks the early stage venture firm’s first fund designed to invest in series B rounds and later. “While we spend most of our time working with companies that are just getting started,” said Sean O’Sullivan, managing partner at SOSV, “many of our 3-to-5-year-old startups are hitting the tens-of-millions-in-revenue level that attracts later stage investors. The new Select Fund will help us keep pace with those opportunities in the years ahead.”
Climeworks' Dr. Christoph Gebald to speak at the SOSV Climate Tech Summit
Swiss DAC startup Climeworks co-founder and co-CEO, Dr. Christoph Gebald, will tackle that question and many others at the SOSV Climate Tech Summit (Oct. 25-26 / free & virtual / register now). Climeworks is a Zurich-based direct-air-capture startup that in September 2021 launched Orca, a production direct-air-capture facility in Iceland, and in April this year became a unicorn following a $639 million round led by co-led by Partners Group and GIC and including John Doerr, Baillie Gifford, and Carbon Removal Partners, among others.
Climate Summit: Hear from At One Ventures, E²JDJ, Material Impact and SOSV on what it takes to win that seed stage check
Who are they writing checks to and why? Which climate technologies are underrated, which are overrated, and which are just emerging?
Climate Tech Analysts: Taking the Temperature with Bloomberg NEF, CTVC, and Voyager VC
What can analysts teach us about their research methods as well as the trends, data points, and unknowns shaping climate tech? Two career analysts and one analyst-turned-VC will address that question.
Industrial processes generate a quarter of global CO2. SepPure, Rondo and OzoneBio aim to decarbonize how things get made
Every sector wants to decarbonize. Perhaps none will have a harder time of it than industry, as the materials and products we use daily often rely on fossil fuels for energy, heat, and feedstock.
SOSV’s HAX program officially opens doors to its new HQ in Newark, NJ
When you walk through HAX’s glass doors at 2 Cedar Street in Newark, New Jersey, a giant orange robot arm greets you, perched over a massive installation where Silana’s founders are working on automated robotic sewing machines.
Announcing the fourth annual SOSV Climate Tech Summit
SOSV’s fourth Climate Tech Summit (Oct. 14-18) is going to be our most intense yet. Investment is down at every stage, and yet phenomenal startups are breaking through in every category, often with huge rounds.
Sleeping Beauty
In a timeless dilemma for new parents, Radhika and her husband Bharath discovered early that their baby daughter was a fussy sleeper. The situation left them tired and frustrated; being effective at work became a challenge.
Lessons Learned from SOSV’s 400 Deep Tech Investments
SOSV Founder and Managing Partner Sean O’Sullivan started investing in what is now called Deep Tech soon after the 1994 IPO of MapInfo, the pioneer in street maps he co-founded. Over 25 years later, SOSV has backed over 400 deep tech startups, out of the 1000+ companies in portfolio. In December 2021, Sean shared some of the lessons learned in an extended fireside side and Q&A session in Paris during the Hello Tomorrow deep tech conference in Paris.
Five SOSV HAX startups shine at CES 2022
The annual Consumer Electronics Show (CES) in Las Vegas wrapped last week, and five companies from SOSV’s HAX portfolio came away with awards and press coverage that rocked “the most influential tech event in the world.”
Getting attention from your first word: Top tips for memorable pitches.
You only have a couple of seconds to grab people’s attention these days before they stop listening to you and start fiddling with their smartphone. No matter how much you love your new company name, it is not going to keep their eyes up and their ears open.
Meet Stephen Chambers, the newly promoted general partner at SOSV's IndieBio NY
Two years after starting the IndieBio NY program as its Managing Director, Dr. Stephen Chambers, PhD, SOSV named him a general partner.
Meet Oscar Ramos, the newly promoted general partner at SOSV's Orbit Startups
At SOSV, Oscar has worked closely with over 160 startups. He and William Bao Bean are responsible for Orbit Startups, which focuses on high growth companies in emerging and frontier markets. We asked Oscar a few questions about his background and work at Orbit Startups.
Amid vegan ingredient shortage, IndieBio’s NotCo taps AI for plant-based alternatives
Plant-based food producer NotCo (IndieBio SF05 2017) has a secret weapon against critical supply chain disruptions, according to Bloomberg’s recent article, “The AI Platform Behind a Bezos-Backed Startup’s Vegan Burgers”. The Chilean-based company is tapping into an artificial intelligence platform named Giuseppe to find an alternative to sunflower oil—a crucial ingredient in one-third of all […]
The US Department of Energy's Jigar Shah to speak at the SOSV Climate Tech Summit
Jigar Shah is appearing at the SOSV Climate Tech Summit Oct. 25-26
HAX's Flair closes $7.6M to redefine home energy consumption
Flair (HAX 06), a startup that produces smart HVAC vents for residential homes, recently raised $7.6 million in a series A, according to TechCrunch in “Smart vent startup Flair nabs $7.6M Series A to decarbonize buildings”. The funding was led by Active Impact Investments and Lowercarbon Capital with support from previous investors SOSV, Skyview, and […]
NotCo's plant-based foods are on store shelves, but its AI engine "Giuseppe" is the real business
While it might look like a plant-based food company, NotCo is in the data and AI business—and aims to disrupt R&D in many industries that use animal and plant ingredients.
SOSV's hard tech program HAX moves closer to Newark HQ grand opening
NJBIZ recently caught up with Ji Ke, SOSV partner and CTO of SOSV’s hard tech program HAX, to talk about the progress and plans for the future NJ home of the program. Ke said he is inspired by the developments he sees in real-time at HAX, as construction continues and the new teams arrive — each bringing […]
Cauldron Ferm lands $6.25M to revolutionize precision fermentation
Cauldron Ferm, based out of Orange, Australia, has raised $6.25 million in a Series A round led by Horizons Ventures to scale its continuous fermentation or “hyper-fermentation” tech, which deploys a novel bioreactor design and proprietary growth medium formulation to improve the economics of large scale fermentation production by five times compared to current industry […]
Announcing HAX's May 1st Demo Day
Investors! Join HAX in Newark on May 1st for Demo Day featuring 20+ startups across climate, industry, and health.
SOSV Closes $306M Deep Tech Fund for Human and Planetary Health
SOSV announced the close of its $306 million SOSV V fund, the firm’s largest fund to date. The news received coverage in TechCrunch, Bloomberg and Axios. The text below is from the press release SOSV issued on April 16th concerning the new fund. SOSV V will focus on deep tech startups in human and planetary health, […]
Announcing HAX’s Sept. 11 San Francisco Demo Day
SOSV’s HAX is holding a demo day in San Francisco on September 11. Join us to hear pitches from 25 startups categories including industrial and maritime decarbonization, critical minerals, automation, diagnostics and more. Following the founders’ pitches, investors will have an opportunity to meet 1:1 with the founders and join the founders and HAX team for a […]
IndieBio New York is excited to support the NY Climate Innovation Ecosystem during New York Climate Week 2024
’s IndieBio New York is proud to host and participate in New York Climate Week events throughout the week, spotlighting the transformative potential of deep tech solutions in driving sustainability across human and planetary health.
Announcing IndieBio New York's February 12 Demo Day
Investors! Join IndieBio in New York on February 12, 2025 for Demo Day featuring 15 startups across climate and health.
Announcing SOSV’s Women’s Health VC-Founder Matchup - February 3–7
Women’s health is gaining attention as a critical area for research, innovation, and investment. In its January 2024 report, McKinsey estimated that “Investments addressing the women’s health gap could add years to life and life to years—and potentially boost the global economy by $1 trillion annually by 2040”. Venture investment in startups focused on disease […]
Can you tell your GC-MS from your TGA or XRF? HAX has them all and more.
In this video, SOSV partner and HAX Chief Science Officer Susan Schofer, PhD gives SOSV founder Sean O’Sullivan a tour of the HAX Analytics Laboratory.
IndieBio NY's Demo Day Kickoff Video
SOSV’s IndieBio NY just held a demo day at its offices in Manhattan. Fifteen spectacular deep tech founders tackling human and planetary health took the stage in front of a packed audience of investors. The IndieBio NY team made this terrific video to kick off the event and introduce the main deep tech themes of […]
Hyperlume Raises $12.5M Seed Round to Solve for Latency and Energy Consumption in Data Centers
Ottawa-based Hyperlume, a 2023 graduate of SOSV’s HAX program, has secured a $12.5 million seed funding round to advance its innovative optical interconnect solutions for AI data centers and high-performance computing systems. The round was led by BDC Capital’s Deep Tech Venture Fund and ArcTern Ventures, with participation from MUUS Climate Partners, Intel Capital, and SOSV
Congrats to SOSV's Fast Company World Changing Idea Winners: Oobli & RxAll
Every year, Fast Company’s World Changing Ideas Awards spotlight the startups, researchers, and organizations pushing bold, creative solutions to our planet’s most urgent challenges. According to Fast Company, the overarching takeaway this year is that, “yes, the world right now feels very bleak. But read through the winners, and you’ll be inspired by the countless […]
Nascent Materials emerges from stealth with $2.3M to make LFP batteries better & cheaper
Today’s lithium-ion batteries are powering the electric world. But behind the scenes, the supply chain is fragile, costly, and overwhelmingly reliant on China, which produced 77% of the world’s batteries in 2022, with the U.S., in comparison, just 6%. That’s why we’re excited to back Nascent Materials, a HAX graduate rethinking how battery materials are […]
YPlasma raises $2.5M to cool the air around chips for data centers
The AI era has brought unprecedented computational power…and with it, unprecedented heat. As chips grow denser and data centers swell, conventional cooling systems are hitting their limits. That’s why we’re excited to unveil our portfolio company YPlasma, which recently announced a $2.5M seed round led by Faber, with participation from SOSV to commercialize its solid-state […]
Announcing the Agenda for the 5th Annual SOSV Climate Tech Summit
We just dropped the agenda for the SOSV Climate Tech Summit and it’s loaded with the investors doubling down on climate and the founders delivering on market share and decarbonization. In the great words of Warren Buffet, “only when the tide goes out do you discover who’s been swimming naked.” And our lineup? Fully suited […]
WTiN Examines the Materials Transition with Po Bronson
In a recent interview with World Textile Information Network (WTiN), SOSV General Partner Po Bronson spoke about the state of innovation in materials and textiles. See the full Q&A below: Q: In the context of the industry’s materials transition, what factors and focuses do you see as being critical over the next five years? I’ve […]
Cayuga Closes $8M Seed Funding & Doses First Patient in Phase 1 Clinical Trial
We’re excited to share two major milestones from our SOSV portfolio company Cayuga, which is developing a novel therapeutic approach to address life-threatening hemorrhage. Hemorrhage causes nearly 2 million deaths each year worldwide, and remains a leading cause of death in surgery, trauma, childbirth, and among patients on blood thinners. Yet current treatments often fail […]
Announcing SOSV's VC-Founder Energy Matchup March 2-6
Announcing the 2026 VC-Founder Energy Matchup, with meetings taking place online between March 2nd (Monday) and March 6th (Friday). This virtual event will bring together 250+ startups and 250+ investors for 1:1 meetings online, scheduled at mutually convenient times. [UPDATE – FEB 19] 282 Startups and 373 Investors have already registered!Investors include Air Liquide, BDC […]
Q&A: FloUV, A UV-C Solution for Food Safety
The megatrend reshaping the food and beverage industry is now crystal clear. People want everything they eat and drink to be healthier and more nutritious. There’s a hidden piece to meeting this challenge. It turns out that the thermal pasteurization process used ubiquitously to make food safe from contamination is silently degrading flavors, aromas, colors, […]
Q&A: SuperCool Earth, Ending Global Water Bankruptcy
It’s no secret that water scarcity is massively reshaping core industries ranging from agriculture to energy. Access to reliable precipitation is now a critical infrastructure priority with government programs, utility companies, and private capital scrambling to find solutions. Surprisingly, the problem is not from a lack of water in clouds. There’s more water in a single […]
Cayuga: Treating All Forms of Bleeding
Cayuga Biotech is a preclinical therapeutics company whose lead compound, CAY001, shows promise to change the way that severe bleeding episodes are treated. We spoke with CEO Damien Kudela, who explained the science and path forward for Cayuga. Watch and read an abbreviated version of the conversation below. How did you transition from academia to biotech […]
Canaery: Digitizing the unseen world of scent
Canaery leverages the animal kingdom’s superior sense of smell to detect and digitize the world of scent.
BioROSA: Early Blood Test for Autism
BioROSA is building a blood-based test for diagnosing autism. Autism currently is diagnosed at age four, on average, with behavioral testing.
Breaking Cancer’s Immune Defenses from the Inside Out, a Conversation with Karma Biotechnologies
We talked with three key team members of Los Angeles-based Karma Biotech – Andrew Gray, Co-Founder and CEO, Alan Johnson, Co-Founder and COO, and Joe Turner, CFO and CBO — in the basement of IndieBio last week after their company had just been voted “Killer of the Week” by their peers in Batch 14.
Wayfinder: Engineering the Future of Smart Biotechnology
Wayfinder’s biosensors are not simply on-off switches, but are capable of analytically sensing specific molecules, in real time.
Avalo.ai: The David & Goliath of Large Genomic Models
Of all the languages an AI could master, without a doubt one of the hardest and most impactful is the genetic language of life itself. So while our world is enthralled with the ability of LLMs to understand all human languages and programming languages, these LLMs also now understand the symbolic languages of math and musical […]
🎥 Heat Beneath Our Feet: Unlocking Superhot Geothermal with Carlos Araque, Quaise Energy
At our latest SOSV Deep Tech Live, we sat down with Carlos Araque, the CEO and founder of Quaise Energy, to discuss energy’s biggest challenge. But first, to understand Quaise, you have to understand the math of energy. Today, it takes 25 terawatts to power the world. But that number doubles every 25 to 30 […]
Metabolic Thinks Diet Can Influence Serious Mental Health Disorders
SOSV portfolio company Metabolic Psychiatry Labs is helping redefine how we understand mental health. Founder and CEO Dr. Shebani Sethi, a Stanford University researcher, studies the role of metabolic dysfunction in conditions like depression, schizophrenia, and other disorders. This week, she published a new peer-reviewed paper in Nature Mental Health and spoke to STAT News […]
SOSV Deep Tech Live - The Atomic Architect: Rick Gottscho on Plasma's Role in Semiconductor Fabrication & Physical AI Infrastructure
Plasma is the foundational technology behind semiconductor fabrication — and without it, Moore’s Law would have stalled decades ago. Now, as silicon transistors hit their physical limits, the industry is turning to new materials, chip architectures, advanced packaging, and novel device physics to sustain performance gains, improve energy efficiency, and reduce compute costs, all while navigating the explosive demand driven by AI. At this critical inflection point, we’re joined by Dr. Rick Gottscho, Retired Head of Products & CTO of Lam Research, who will make the case for why plasma’s most important moment is right now.
Announcing the SOSV Deep Tech Summit, coming November 4-6
The SOSV Deep Tech Summit focuses on three areas: climate tech, human health, and AI for the physical world.